Frederick Mershimer was born in Sharon, Pennsylvania and majored in painting and drawing at Carnegie-Mellon University from 1976 to 1980. He moved to New York in 1983 where he was introduced to mezzotint process, which has been his primary means of expression. Mershimer further developed his talents in graphics and fine art printmaking through studies at the New School, Pratt Graphic Center and Manhattan Graphic Center. In 2007, Stone and Press Gallery published a catalogue raisonné titled Frederick Mershimer: Mezzotints 1984-2006. The book covers his entire oeuvre during those years. In 2009 the U.S. Government granted him a patent for a machine he developed to prepare mezzotint plates.
Collections, including, the Brooklyn Museum of Art, the Cleveland Museum of Art, Detroit Institute of Art, the Museum of the City of New York, The National Museum of American Art/Smithsonian, the New Orleans Museum of Art, and the Whitney Museum of American Art.